By using breakthrough systems biology approaches, NIMSB aims to better understand human biology and to contribute to medical innovation with great potential to benefit patients. To address these challenges, NIMSB is creating necessary infrastructure in state-of-the-art technology areas in cooperation with NOVA and MDC. NIMSB Technology Platforms will support front-end application of technologies, will provide access to equipment, training and consultation in methodologies, and will be involved in collaborative research projects and technology developments.
OMICS & DATA ANALYSIS
State-of-the-art single-cell genomics technologies and next-generation sequencing. Consultation for experimental design, sample processing and data analysis.
Advanced mass spectrometry-based, proteomics metabolomics and lipidomics. Shotgun and targeted approaches. Support for sample preparation and data analysis.
Bioinformatics tools, statistical analysis, and machine-learning methods for large datasets derived from high throughput omics approaches. Consultation for experimental design and project planning.
DISEASE MODELS
Expertise on deriving organoids from progenitors ot pluripotent stem cells, genetically modifying them and developing methods for characterization. Advise on setting up organ-on-a-chip experimental systems.
Clinicians would like to intervene earlier and to understand better the development of a disease to make targeted therapeutic decisions for each person. Researchers are eager to see their discoveries reach the clinic — where they can make a real difference. The Clinical Science Initiative at NIMSB was created to bridge this gap.
Our goal is to support you in accessing, understanding, and co-developing innovative technologies that respond to your clinical priorities. Whether you are looking to explore novel biomarkers, or integrate multi-omics approaches into patient stratification, the Clinical Science Initiative is here to collaborate and to innovate with you.
This department is being led by Dr. Cláudia Queiroga, who has 10 years of experience in the biomedical research and has worked in the clinical environment for 7 years in Portugal and internationally.
The success of a treatment often depends on the early disease detection
Nowadays, the therapy for a disease is given to a patient once a diagnosis is made, when the disease is already manifesting symptoms. Frequently, earlier intervention leads to higher success rates.
The organism exhibits changes in homeostasis even before the disease symptoms arise.
In addition, a deeper understanding of disease dynamics opens the door to identifying the most effective therapeutic strategies for each patient. This represents a critical window for intervention, where we propose to take action.
Technological platforms to foster medical innovation with real potential to improve patient care
At NIMSB, we are developing cutting-edge technological platforms designed to enhance our understanding of diseases, identify early biomarkers, track disease progression, and explore ways to intervene, guiding the body back to a state of homeostasis.
These platforms will be equipped with state-of-the-art equipment and supported by a multidisciplinary team of experts who bring deep analytical and biological insight through collaborative scientific partnerships.
