Systems Biology for Medical Innovation and Precision Medicine

A major barrier to the early detection and diagnosis of chronic diseases, as well as selecting the most effective therapy for an individual patient, is the insufficient understanding of the disease at the cellular level.

The NIMSB mission is to pioneer excellent interdisciplinary research aimed at detecting the earliest cellular changes that trigger the onset of disease. Such unprecedented, sensitive, and precise detection is made possible by the emergence and integration of new breakthrough technologies, including single-cell and spatial multi-omics, artificial intelligence, and patient-derived disease models (organoids and organ-on-a-ship).

Timely detection and successful treatment of disease depend crucially on understanding and defining when, why, and how cells deviate from healthy states in specific patient groups, based on their genetic background and environmental history. Health research in diverse human populations is key for more inclusive and precise treatments within Europe and worldwide.

Discovering the earliest causative pathological cellular changes will be translated through proactive innovation programs into novel diagnostics with increased accuracy for disease detection even before symptoms arise, creating unforeseen therapeutic opportunities to intercept disease and cure patients before irreparable damage to tissues and organs.