Research António Jacinto

Pipette adding fluid to one of several test tubes - Pipette adding fluid to one of several test tubes
claudia-santos

Cláudia Nunes Santos

Principal Investigator

Team

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Natasa Loncarevic- Vasiljkovic

Senior Post-Doctoral Researcher

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Inês Figueira

Post-Doctoral Researcher

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Paulo Bastos

Post-Doctoral Researcher

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Rúben Rodrigues

Post-Doctoral Researcher

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Ana Filipa Raimundo

Lab Manager

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Catarina Pinto

PhD Student

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Daniela Marques

PhD Student

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Diogo Carregosa

PhD Student

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Liza Hilman

PhD Student

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Rafael Carecho

PhD Student

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Rita Ramos

PhD Student

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Carlos Pita

MSc

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Inês Silva

MSc

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Bernardo Rocha

MSc Student

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Diogo Moura-Louro

MSc Student

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Hugo Taínha

MSc Student

We aim to understand the nutrition-related mechanisms of cellular processes at the molecular level and associated to lifestyle-related chronic illnesses.

We are particularly interested in the study of polyphenol metabolism in humans and animal models by metabolomics approaches, i.e., bioaccessibility, bioavailability, brain permeability and cellular metabolism, as well as polyphenol metabolites bioactivity towards neurodegenerative diseases, focusing on Parkinson’s disease, neurodegeneration, neuroinflammation and in blood- brain barrier dysfunction.

We perform mechanistic studies using yeast, state of art cellular and animal models of disease, and molecular approaches to unravel the molecular mechanisms of cytoprotection mediated by polyphenol-derived metabolites.




  • FCT exploratory project, PERCEPT – Parkinson’s disEase bRain-Chip modEl to unveil Polyphenols potential, 2022.02127.PTDC (01/01/2023 – 30/06/2024)- IR: Inês Figueira
  • ERC-2018-Starting grant,LIMBo-Zooming the link between diet and brain health: how phenolic metabolites modulate brain inflammation. (1/4/2019-31/3/2024) (in collaboration with iBET-Instituto de Biologia Experimental e Tecnológica)
  • H2020 project, CHIC-Chicory as a multipurpose crop for dietary fibre and medicinal terpenes. (1/1/2018-30/6/2022) (in collaboration with iBET-Instituto de Biologia Experimental e Tecnológica)
  • FP7 project, BacHBerry-BACterial Hosts for production of Bioactive phenolics from bERRY fruits. (29/10/2013-31/10/2016) (in collaboration with iBET)
  • FP7 project, EUBerry: The sustainable improvement of European berry production, quality and nutritional value in a changing environment. (1/5/2011-31/10/2014) (in collaboration with iBET)
  • FCT project, Therapeutics@DIAPP_Perceiving Diabetes as an Islet Amyloid PolyPeptide oligomeropathy: disease progression and therapeutic focus. (in collaboration with iBET)
  • Inova4health project, TherDIAPP_Islet Amyloid Polypeptide oligomers as critical entities in diabetes: early diagnosis and therapeutic focus. (1/1/2018-31/12/2018) (in collaboration with iBET)
  • FCT/ANR project, CardioBDP- Mechanisms of Cardioprotection by Berries-driven Polyphenols. (1/2/2014-31/07/2017) (in collaboration with iBET)
  • Fundo EDP para a Biodiversidade 2010/2012: ”Conservation and Recovery of Threatened endemic Flora in Portugal”. (in collaboration with iBET)
  • FCT project, Polyphenols as protective agents in cellular models of alpha-synucleinopaties, in particular Parkinson’s disease, (in collaboration with ITQB)