OWERVIEW

Overview of your research here!

 

Main interests                            Methods                                 Models

 

 

STRATEGY

 

PROJECTS

Molecular mechanisms of retinal regeneration

Why can zebrafish regenerate their retina while humans cannot? Can we activate the same regenerative potential in the human eye to restore vision?

To address these questions, we study how retinal cells respond to injury, focusing on Müller glia—specialized support cells that drive regeneration in zebrafish but remain inactive in humans. Using zebrafish and human retinal organoids, we investigate the molecular and metabolic mechanisms that control this process.

Our research has identified a key metabolic switch that occurs after injury in zebrafish, producing metabolites that activate Müller glia and trigger regeneration. We aim to understand how these metabolic signals work and whether similar pathways can be activated in human cells.

By combining molecular, cellular, and metabolic approaches, our goal is to uncover the mechanisms that enable retinal regeneration and use this knowledge to develop new therapies that could one day restore vision in patients with retinal diseases.

 

MERIT-H – Deciphering and Targeting Metabolic–Epigenetic Reprogramming of Cancer-Associated Fibroblasts to Improve Therapy Response in Hepatocellular Carcinoma

TEXT OF A PROJECT HERE!